MnTE-2-PyP(5+) acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics and enhance the response to chemotherapy in lymphoma cells

The manganese porphyrin, manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin (MnTE-2-PyP(5+)), acts as a pro-oxidant in the presence of intracellular H(2)O(2). Mitochondria are the most prominent source of intracellular ROS and important regulators of the intrinsic apoptotic pathway. Due...

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Bibliographic Details
Published in:Free Radic Biol Med
Main Authors: Jaramillo, Melba C., Briehl, Margaret M., Batinic-Haberle, Ines, Tome, Margaret E.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441837/
https://ncbi.nlm.nih.gov/pubmed/25725417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.01.031
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