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Viral receptor-binding site antibodies with diverse germline origins

Vaccines for rapidly evolving pathogens will confer lasting immunity if they elicit antibodies recognizing conserved epitopes, such as a receptor-binding site (RBS). From characteristics of an influenza-virus RBS-directed antibody, we devised a signature motif to search for similar antibodies. We id...

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Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Schmidt, Aaron G., Therkelsen, Matthew D., Stewart, Shaun, Kepler, Thomas B., Liao, Hua-Xin, Moody, M. Anthony, Haynes, Barton F., Harrison, Stephen C.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441819/
https://ncbi.nlm.nih.gov/pubmed/25959776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.04.028
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