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Fragment-based approaches to enzyme inhibition
Fragment-based approaches have provided a new paradigm for small-molecule drug discovery. The methodology is complementary to high-throughput screening approaches, starting from fragments of low molecular complexity and high ligand efficiency, and building up to more potent inhibitors. The approach,...
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| Vydáno v: | Curr Opin Biotechnol |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4441723/ https://ncbi.nlm.nih.gov/pubmed/17959370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.copbio.2007.09.003 |
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