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Fragment-based approaches to enzyme inhibition

Fragment-based approaches have provided a new paradigm for small-molecule drug discovery. The methodology is complementary to high-throughput screening approaches, starting from fragments of low molecular complexity and high ligand efficiency, and building up to more potent inhibitors. The approach,...

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Publicat a:Curr Opin Biotechnol
Autors principals: Ciulli, Alessio, Abell, Chris
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441723/
https://ncbi.nlm.nih.gov/pubmed/17959370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.copbio.2007.09.003
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