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A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry

A new strategy that combines the concepts of fragment-based drug design and dynamic combinatorial chemistry (DCC) for targeting adenosine recognition sites on enzymes is reported. We demonstrate the use of 5′-deoxy-5′-thioadenosine as a noncovalent anchor fragment in dynamic combinatorial libraries...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Scott, Duncan E., Dawes, Gwen J., Ando, Michiyo, Abell, Chris, Ciulli, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458376/
https://ncbi.nlm.nih.gov/pubmed/19827080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200900537
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