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Thioamide substitution to probe the hydroxyproline recognition of VHL ligands
Thioamide substitution influences hydrogen bond and n → π(∗) interactions involved in the conformational stability of protein secondary structures and oligopeptides. Hydroxyproline is the key recognition element of small molecules targeting the von Hippel-Lindau (VHL) E3 ligase, which are of interes...
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| Published in: | Bioorg Med Chem |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Elsevier Science
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6008493/ https://ncbi.nlm.nih.gov/pubmed/29650462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.03.034 |
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