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Disrupting the Constitutive, Homodimeric Protein–Protein Interface in CK2β Using a Biophysical Fragment-Based Approach

[Image: see text] Identifying small molecules that induce the disruption of constitutive protein–protein interfaces is a challenging objective. Here, a targeted biophysical screening cascade was employed to specifically identify small molecules that could disrupt the constitutive, homodimeric protei...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Seetoh, Wei-Guang, Abell, Chris
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2016
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5257173/
https://ncbi.nlm.nih.gov/pubmed/27726344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b07440
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