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Disrupting the Constitutive, Homodimeric Protein–Protein Interface in CK2β Using a Biophysical Fragment-Based Approach
[Image: see text] Identifying small molecules that induce the disruption of constitutive protein–protein interfaces is a challenging objective. Here, a targeted biophysical screening cascade was employed to specifically identify small molecules that could disrupt the constitutive, homodimeric protei...
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| Publicado no: | J Am Chem Soc |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2016
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5257173/ https://ncbi.nlm.nih.gov/pubmed/27726344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b07440 |
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