TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation

Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system. We report here that TSC1 differentially regulates mTOR complex 1 (mTORC1) and mTORC2/Akt signaling in B cells. TSC1 d...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Ci, Xinxin, Kuraoka, Masayuki, Wang, Hongxia, Carico, Zachary, Hopper, Kristen, Shin, Jinwook, Deng, Xuming, Qiu, Yirong, Unniraman, Shyam, Kelsoe, Garnett, Zhong, Xiao-Ping
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441391/
https://ncbi.nlm.nih.gov/pubmed/26000908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127527
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