iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions

Terminal maturation of invariant NKT (iNKT) cells from stage 2 (CD44(+)NK1.1(–)) to stage 3 (CD44(+)NK1.1(+)) is accompanied by a functional acquisition of a predominant IFN-γ–producing (iNKT-1) phenotype; however, some cells develop into IL-17–producing iNKT (iNKT-17) cells. iNKT-17 cells are rare...

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Main Authors: Wu, Jinhong, Yang, Jialong, Yang, Kai, Wang, Hongxia, Gorentla, Balachandra, Shin, Jinwook, Qiu, Yurong, Que, Loretta G., Foster, W. Michael, Xia, Zhenwei, Chi, Hongbo, Zhong, Xiao-Ping
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973110/
https://ncbi.nlm.nih.gov/pubmed/24614103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69780
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