AID Expression and Activity in the Absence of Germinal Centers: Insights into Hyper-IgM Syndrome

Somatic hypermutation (SHM) normally occurs as a consequence of the expression of activation-induced cytidine deaminase (AID) by antigen-activated, mature B cells during T cell-dependent (T(d)) germinal center (GC) responses. Nonetheless, despite their inability to express CD154 and initiate GC resp...

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Библиографические подробности
Главные авторы: Kuraoka, Masayuki, Liao, Dongmei, Yang, Kaiyong, Allgood, Sallie D., Levesque, Marc C., Kelsoe, Garnett, Ueda, Yoshihiro
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779701/
https://ncbi.nlm.nih.gov/pubmed/19667096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901548
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