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AID Expression and Activity in the Absence of Germinal Centers: Insights into Hyper-IgM Syndrome
Somatic hypermutation (SHM) normally occurs as a consequence of the expression of activation-induced cytidine deaminase (AID) by antigen-activated, mature B cells during T cell-dependent (T(d)) germinal center (GC) responses. Nonetheless, despite their inability to express CD154 and initiate GC resp...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2779701/ https://ncbi.nlm.nih.gov/pubmed/19667096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901548 |
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