Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for over 100,000 disease-associated variants. Here we functionally profile several t...

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izdano v:Cell
Main Authors: Sahni, Nidhi, Yi, Song, Taipale, Mikko, Fuxman Bass, Juan I., Coulombe-Huntington, Jasmin, Yang, Fan, Peng, Jian, Weile, Jochen, Karras, Georgios I., Wang, Yang, Kovács, István A., Kamburov, Atanas, Krykbaeva, Irina, Lam, Mandy H., Tucker, George, Khurana, Vikram, Sharma, Amitabh, Liu, Yang-Yu, Yachie, Nozomu, Zhong, Quan, Shen, Yun, Palagi, Alexandre, San-Miguel, Adriana, Fan, Changyu, Balcha, Dawit, Dricot, Amelie, Jordan, Daniel M., Walsh, Jennifer M., Shah, Akash A., Yang, Xinping, Stoyanova, Ani, Leighton, Alex, Calderwood, Michael A., Jacob, Yves, Cusick, Michael E., Salehi-Ashtiani, Kourosh, Whitesell, Luke J., Sunyaev, Shamil, Berger, Bonnie, Barabási, Albert-László, Charloteaux, Benoit, Hill, David E., Hao, Tong, Roth, Frederick P., Xia, Yu, Walhout, Albertha J.M., Lindquist, Susan, Vidal, Marc
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441215/
https://ncbi.nlm.nih.gov/pubmed/25910212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.04.013
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