Quiescent Sox2(+) Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2(+) cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism that mirrors a neurogenic program. Rare Sox2(+) cells produce rapidly cycling doublecorti...

詳細記述

保存先:
書誌詳細
出版年:Cancer Cell
主要な著者: Vanner, Robert J., Remke, Marc, Gallo, Marco, Selvadurai, Hayden J., Coutinho, Fiona, Lee, Lilian, Kushida, Michelle, Head, Renee, Morrissy, Sorana, Zhu, Xueming, Aviv, Tzvi, Voisin, Veronique, Clarke, Ian D., Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M., Marra, Marco A., Malkin, David, Northcott, Paul A., Kool, Marcel, Pfister, Stefan M., Bader, Gary, Hochedlinger, Konrad, Korshunov, Andrey, Taylor, Michael D., Dirks, Peter B.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441014/
https://ncbi.nlm.nih.gov/pubmed/24954133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.05.005
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料