Quiescent Sox2(+) Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2(+) cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism that mirrors a neurogenic program. Rare Sox2(+) cells produce rapidly cycling doublecorti...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Cell
Prif Awduron: Vanner, Robert J., Remke, Marc, Gallo, Marco, Selvadurai, Hayden J., Coutinho, Fiona, Lee, Lilian, Kushida, Michelle, Head, Renee, Morrissy, Sorana, Zhu, Xueming, Aviv, Tzvi, Voisin, Veronique, Clarke, Ian D., Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M., Marra, Marco A., Malkin, David, Northcott, Paul A., Kool, Marcel, Pfister, Stefan M., Bader, Gary, Hochedlinger, Konrad, Korshunov, Andrey, Taylor, Michael D., Dirks, Peter B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441014/
https://ncbi.nlm.nih.gov/pubmed/24954133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.05.005
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