Llwytho...
Quiescent Sox2(+) Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma
Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2(+) cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism that mirrors a neurogenic program. Rare Sox2(+) cells produce rapidly cycling doublecorti...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Cancer Cell |
|---|---|
| Prif Awduron: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2014
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4441014/ https://ncbi.nlm.nih.gov/pubmed/24954133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.05.005 |
| Tagiau: |
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