Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats

We have previously shown that incubation for 1h with excess glucose or leucine causes insulin resistance in rat extensor digitorum longus (EDL) muscle by inhibiting AMP-activated protein kinase (AMPK). To examine the events that precede and follow these changes, studies were performed in rat EDL inc...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Coughlan, Kimberly A., Balon, Thomas W., Valentine, Rudy J., Petrocelli, Robert, Schultz, Vera, Brandon, Amanda, Cooney, Gregory J., Kraegen, Edward W., Ruderman, Neil B., Saha, Asish K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440828/
https://ncbi.nlm.nih.gov/pubmed/25996822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127388
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