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Insulin resistance due to nutrient excess: Is it a consequence of AMPK downregulation?

It has long been known that excesses of glucose and branched chain amino acids, such as leucine, lead to insulin resistance in skeletal muscle. A recent study in incubated rat muscle suggests that both molecules may do so by virtue of their ability to downregulate the fuel sensing and signaling enzy...

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Detalhes bibliográficos
Main Authors: Saha, Asish K, Xu, X. Julia, Balon, Thomas W, Brandon, Amanda, Kraegen, Edward W, Ruderman, Neil B
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356833/
https://ncbi.nlm.nih.gov/pubmed/22067655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.20.17886
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