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Insulin resistance due to nutrient excess: Is it a consequence of AMPK downregulation?
It has long been known that excesses of glucose and branched chain amino acids, such as leucine, lead to insulin resistance in skeletal muscle. A recent study in incubated rat muscle suggests that both molecules may do so by virtue of their ability to downregulate the fuel sensing and signaling enzy...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Landes Bioscience
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3356833/ https://ncbi.nlm.nih.gov/pubmed/22067655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.20.17886 |
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