Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats

We have previously shown that incubation for 1h with excess glucose or leucine causes insulin resistance in rat extensor digitorum longus (EDL) muscle by inhibiting AMP-activated protein kinase (AMPK). To examine the events that precede and follow these changes, studies were performed in rat EDL inc...

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Veröffentlicht in:PLoS One
Hauptverfasser: Coughlan, Kimberly A., Balon, Thomas W., Valentine, Rudy J., Petrocelli, Robert, Schultz, Vera, Brandon, Amanda, Cooney, Gregory J., Kraegen, Edward W., Ruderman, Neil B., Saha, Asish K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440828/
https://ncbi.nlm.nih.gov/pubmed/25996822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127388
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