TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation

The Epstein-Barr virus (EBV) encoded oncoprotein Latent Membrane Protein 1 (LMP1) signals through two C-terminal tail domains to drive cell growth, survival and transformation. The LMP1 membrane-proximal TES1/CTAR1 domain recruits TRAFs to activate MAP kinase, non-canonical and canonical NF-kB pathw...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Greenfeld, Hannah, Takasaki, Kaoru, Walsh, Michael J., Ersing, Ina, Bernhardt, Katharina, Ma, Yijie, Fu, Bishi, Ashbaugh, Camille W., Cabo, Jackson, Mollo, Sarah B., Zhou, Hufeng, Li, Shitao, Gewurz, Benjamin E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440769/
https://ncbi.nlm.nih.gov/pubmed/25996949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004890
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