Evasion of affinity-based selection in germinal centers by Epstein–Barr virus LMP2A

Epstein–Barr virus (EBV) infects germinal center (GC) B cells and establishes persistent infection in memory B cells. EBV-infected B cells can cause B-cell malignancies in humans with T- or natural killer-cell deficiency. We now find that EBV-encoded latent membrane protein 2A (LMP2A) mimics B-cell...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Minamitani, Takeharu, Yasui, Teruhito, Ma, Yijie, Zhou, Hufeng, Okuzaki, Daisuke, Tsai, Chiau-Yuang, Sakakibara, Shuhei, Gewurz, Benjamin E., Kieff, Elliott, Kikutani, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577157/
https://ncbi.nlm.nih.gov/pubmed/26305967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514484112
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