RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

The Ras/mitogen-activated protein kinase (MAPK) signalling cascade regulates various biological functions, including cell growth, proliferation and survival. As such, this pathway is often deregulated in cancer, including melanomas, which frequently harbour activating mutations in the NRAS and BRAF...

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Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Romeo, Yves, Moreau, Julie, Zindy, Pierre-Joachim, Saba-El-Leil, Marc, Lavoie, Geneviève, Dandachi, Farah, Baptissart, Marine, Borden, Katherine L. B., Meloche, Sylvain, Roux, Philippe P.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440665/
https://ncbi.nlm.nih.gov/pubmed/22797077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.312
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