RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

The Ras/mitogen-activated protein kinase (MAPK) signalling cascade regulates various biological functions, including cell growth, proliferation and survival. As such, this pathway is often deregulated in cancer, including melanomas, which frequently harbour activating mutations in the NRAS and BRAF...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Romeo, Yves, Moreau, Julie, Zindy, Pierre-Joachim, Saba-El-Leil, Marc, Lavoie, Geneviève, Dandachi, Farah, Baptissart, Marine, Borden, Katherine L. B., Meloche, Sylvain, Roux, Philippe P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440665/
https://ncbi.nlm.nih.gov/pubmed/22797077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.312
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