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Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest
Mammalian female meiosis is error prone, with rates of meiotic chromosome missegregations strongly increasing towards the end of the reproductive lifespan. A strong reduction of BubR1 has been observed in oocytes of women approaching menopause and in ovaries of aged mice, which led to the hypothesis...
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| Published in: | Nat Commun |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4439927/ https://ncbi.nlm.nih.gov/pubmed/25897860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7946 |
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