Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest

Mammalian female meiosis is error prone, with rates of meiotic chromosome missegregations strongly increasing towards the end of the reproductive lifespan. A strong reduction of BubR1 has been observed in oocytes of women approaching menopause and in ovaries of aged mice, which led to the hypothesis...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Touati, Sandra A., Buffin, Eulalie, Cladière, Damien, Hached, Khaled, Rachez, Christophe, van Deursen, Jan M., Wassmann, Katja
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4439927/
https://ncbi.nlm.nih.gov/pubmed/25897860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7946
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