Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART

BACKGROUND: Depletion of mucosal Th17 cells during HIV/SIV infections is a major cause for microbial translocation, chronic immune activation, and disease progression. Mechanisms contributing to Th17 deficit are not fully elucidated. Here we investigated alterations in the Th17 polarization potentia...

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Détails bibliographiques
Publié dans:Retrovirology
Auteurs principaux: DaFonseca, Sandrina, Niessl, Julia, Pouvreau, Sylvia, Wacleche, Vanessa Sue, Gosselin, Annie, Cleret-Buhot, Aurélie, Bernard, Nicole, Tremblay, Cécile, Jenabian, Mohammad-Ali, Routy, Jean-Pierre, Ancuta, Petronela
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438463/
https://ncbi.nlm.nih.gov/pubmed/25924895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0164-6
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