Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach

BACKGROUND: The HIV-1 infection is characterized by profound CD4(+) T cell destruction and a marked Th17 dysfunction at the mucosal level. Viral suppressive antiretroviral therapy restores Th1 but not Th17 cells. Although several key HIV dependency factors (HDF) were identified in the past years via...

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Publicado no:Retrovirology
Main Authors: Cleret-Buhot, Aurélie, Zhang, Yuwei, Planas, Delphine, Goulet, Jean-Philippe, Monteiro, Patricia, Gosselin, Annie, Wacleche, Vanessa Sue, Tremblay, Cécile L., Jenabian, Mohammad-Ali, Routy, Jean-Pierre, El-Far, Mohamed, Chomont, Nicolas, Haddad, Elias K., Sekaly, Rafick-Pierre, Ancuta, Petronela
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676116/
https://ncbi.nlm.nih.gov/pubmed/26654242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0226-9
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