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A novel HSP90 inhibitor delays castrate resistant prostate cancer without altering serum PSA levels and inhibits osteoclastogenesis

PURPOSE: Prostate cancer responds initially to anti-androgen therapies, however, progression to castration resistant disease frequently occurs. Therefore there is an urgent need for novel therapeutic agents that can prevent the emergence of castration resistant prostate cancer (CRPC). Hsp90 is a mol...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Lamoureux, Francois, Thomas, Christian, Yin, Min-Jean, Kuruma, Hidetoshi, Fazli, Ladan, Gleave, Martin E, Zoubeidi, Amina
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437585/
https://ncbi.nlm.nih.gov/pubmed/21349995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3077
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