Cell Density Sensing Alters TGF-β Signaling in a Cell-Type-Specific Manner, Independent from Hippo Pathway Activation

Cell-cell contacts inhibit cell growth and proliferation in part by activating the Hippo pathway that drives the phosphorylation and nuclear exclusion of the transcriptional coactivators YAP and TAZ. Cell density and Hippo signaling have also been reported to block transforming growth factor β (TGF-...

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Pubblicato in:Dev Cell
Autori principali: Nallet-Staub, Flore, Yin, Xueqian, Gilbert, Cristèle, Marsaud, Véronique, Ben Mimoun, Saber, Javelaud, Delphine, Leof, Edward B., Mauviel, Alain
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437188/
https://ncbi.nlm.nih.gov/pubmed/25758862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.01.011
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