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Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing
Mutations in the serine/threonine kinase BRAF are found in more than 60% of melanomas. The most prevalent melanoma mutation is BRAF(V600E), which constitutively activates downstream MAPK signaling. Vemurafenib is a potent RAF kinase inhibitor with remarkable clinical activity in BRAF(V600E)-positive...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4435825/ https://ncbi.nlm.nih.gov/pubmed/25971842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8103 |
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