Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice.

Transgenic mice with both alleles of the p53 tumor suppressor gene (frequently mutated in human tumors) knocked out by gene targeting provide a potentially useful tumorigenesis model because these mice rapidly develop spontaneous tumors. To determine whether tumorigenesis in p53-knockout mice is sen...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Hursting, S D, Perkins, S N, Phang, J M
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1994
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44333/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8041741/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.15.7036
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