Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice.
Transgenic mice with both alleles of the p53 tumor suppressor gene (frequently mutated in human tumors) knocked out by gene targeting provide a potentially useful tumorigenesis model because these mice rapidly develop spontaneous tumors. To determine whether tumorigenesis in p53-knockout mice is sen...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1994
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44333/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8041741/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.15.7036 |
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