Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition

BACKGROUND: Malignant melanoma is an aggressive tumor type that often develops drug resistance to targeted therapeutics. The production of colony stimulating factor 1 (CSF-1) in tumors recruits myeloid cells such as M2-polarized macrophages and myeloid derived suppressor cells (MDSC), leading to an...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Mok, Stephen, Tsoi, Jennifer, Koya, Richard C, Hu-Lieskovan, Siwen, West, Brian L, Bollag, Gideon, Graeber, Thomas G, Ribas, Antoni
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432503/
https://ncbi.nlm.nih.gov/pubmed/25939769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1377-8
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