Histone Deacetylase 6 (HDAC6) Promotes the Pro-survival Activity of 14-3-3ζ via Deacetylation of Lysines within the 14-3-3ζ Binding Pocket

The phospho-binding protein 14-3-3ζ acts as a signaling hub controlling a network of interacting partners and oncogenic pathways. We show here that lysines within the 14-3-3ζ binding pocket and protein-protein interface can be modified by acetylation. The positive charge on two of these lysines, Lys...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mortenson, Jeffrey B., Heppler, Lisa N., Banks, Courtney J., Weerasekara, Vajira K., Whited, Matthew D., Piccolo, Stephen R., Johnson, William E., Thompson, J. Will, Andersen, Joshua L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432270/
https://ncbi.nlm.nih.gov/pubmed/25770209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.607580
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