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Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain
Accumulation of unfolded proteins in the endoplasmic reticulum (ER) accompanies ER stress and causes the type-I transmembrane protein Ire1 (also known as ERN1) to trigger the unfolded protein response (UPR). When dimerized, the core stress-sensing region (CSSR) of Ire1 directly captures unfolded pro...
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| Publié dans: | J Cell Sci |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Company of Biologists
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4432228/ https://ncbi.nlm.nih.gov/pubmed/25770101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.164111 |
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