Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) accompanies ER stress and causes the type-I transmembrane protein Ire1 (also known as ERN1) to trigger the unfolded protein response (UPR). When dimerized, the core stress-sensing region (CSSR) of Ire1 directly captures unfolded pro...

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Vydáno v:J Cell Sci
Hlavní autoři: Mathuranyanon, Rubwad, Tsukamoto, Tomoko, Takeuchi, Asumi, Ishiwata-Kimata, Yuki, Tsuchiya, Yuichi, Kohno, Kenji, Kimata, Yukio
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432228/
https://ncbi.nlm.nih.gov/pubmed/25770101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.164111
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