Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways

Eukaryotic cells activate the unfolded-protein response (UPR) upon endoplasmic reticulum (ER) stress, where the stress is assumed to be the accumulation of unfolded proteins in the ER. Consistent with previous in vitro studies of the ER-luminal domain of the mutant UPR initiator Ire1, our study show...

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Main Authors: Promlek, Thanyarat, Ishiwata-Kimata, Yuki, Shido, Masahiro, Sakuramoto, Mitsuru, Kohno, Kenji, Kimata, Yukio
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2011
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172275/
https://ncbi.nlm.nih.gov/pubmed/21775630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-04-0295
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