Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins

Chaperone protein BiP binds to Ire1 and dissociates in response to endoplasmic reticulum (ER) stress. However, it remains unclear how the signal transducer Ire1 senses ER stress and is subsequently activated. The crystal structure of the core stress-sensing region (CSSR) of yeast Ire1 luminal domain...

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Detalhes bibliográficos
Main Authors: Kimata, Yukio, Ishiwata-Kimata, Yuki, Ito, Tatsuhiko, Hirata, Aiko, Suzuki, Tomohide, Oikawa, Daisuke, Takeuchi, Masato, Kohno, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064738/
https://ncbi.nlm.nih.gov/pubmed/17923530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200704166
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