Encoded Library Technology Screening of Hepatitis C Virus NS4B Yields a Small-Molecule Compound Series with In Vitro Replicon Activity

To identify novel antivirals to the hepatitis C virus (HCV) NS4B protein, we utilized encoded library technology (ELT), which enables purified proteins not amenable to standard biochemical screening methods to be tested against large combinatorial libraries in a short period of time. We tested NS4B...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Arico-Muendel, Christopher, Zhu, Zhengrong, Dickson, Hamilton, Parks, Derek, Keicher, Jesse, Deng, Jianghe, Aquilani, Leah, Coppo, Frank, Graybill, Todd, Lind, Kenneth, Peat, Andrew, Thomson, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432136/
https://ncbi.nlm.nih.gov/pubmed/25824229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00070-15
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