Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

Targeted disruption of the c-src proto-oncogene in mice has shown that src expression is required for normal bone resorption, since the src-deficient mutants develop osteopetrosis. To evaluate the mechanisms by which src-deficiency affects osteoclast function, we treated src-deficient mice with the...

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Pubblicato in:	J Clin Invest
Autori principali:	Boyce, B F, Yoneda, T, Lowe, C, Soriano, P, Mundy, G R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443211/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1383278/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116032
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