Herbimycin A, a pp60c-src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo.

Since absence of expression of the c-src gene product in mice indicates that the pp60c-src tyrosine kinase is required and essential for osteoclastic bone resorption, we tested the effects of the antibiotic herbimycin A, which is an inhibitor of pp60c-src on osteoclastic bone resorption in vitro and...

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Pubblicato in:	J Clin Invest
Autori principali:	Yoneda, T, Lowe, C, Lee, C H, Gutierrez, G, Niewolna, M, Williams, P J, Izbicka, E, Uehara, Y, Mundy, G R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443346/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8514886/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116521
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