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Herbimycin A, a pp60c-src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo.

Since absence of expression of the c-src gene product in mice indicates that the pp60c-src tyrosine kinase is required and essential for osteoclastic bone resorption, we tested the effects of the antibiotic herbimycin A, which is an inhibitor of pp60c-src on osteoclastic bone resorption in vitro and...

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Autors principals: Yoneda, T, Lowe, C, Lee, C H, Gutierrez, G, Niewolna, M, Williams, P J, Izbicka, E, Uehara, Y, Mundy, G R
Format: Artigo
Idioma:Inglês
Publicat: 1993
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC443346/
https://ncbi.nlm.nih.gov/pubmed/8514886
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