Relief of opsin desensitization and prolonged excitation of rod photoreceptors by 9-desmethylretinal.

The 9-methyl group of 11-cis-retinal plays a crucial role in photoexcitation of the visual pigment rhodopsin. A hydrogen-substituted analogue, 11-cis-9-desmethylretinal, combines with opsin to form a pigment that produces abnormal photoproducts and diminished activation of the GTP-binding protein tr...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Corson, D W, Cornwall, M C, MacNichol, E F, Tsang, S, Derguini, F, Crouch, R K, Nakanishi, K
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1994
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44317/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8041729/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.15.6958
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