Relief of opsin desensitization and prolonged excitation of rod photoreceptors by 9-desmethylretinal.

The 9-methyl group of 11-cis-retinal plays a crucial role in photoexcitation of the visual pigment rhodopsin. A hydrogen-substituted analogue, 11-cis-9-desmethylretinal, combines with opsin to form a pigment that produces abnormal photoproducts and diminished activation of the GTP-binding protein tr...

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Bibliographic Details
Main Authors: Corson, D W, Cornwall, M C, MacNichol, E F, Tsang, S, Derguini, F, Crouch, R K, Nakanishi, K
Format: Artigo
Language:Inglês
Published: 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC44317/
https://ncbi.nlm.nih.gov/pubmed/8041729
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