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Epigenome editing by a CRISPR/Cas9-based acetyltransferase activates genes from promoters and enhancers
Technologies that facilitate the targeted manipulation of epigenetic marks could be used to precisely control cell phenotype or interrogate the relationship between the epigenome and transcriptional control. Here we have generated a programmable acetyltransferase based on the CRISPR/Cas9 gene regula...
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| Publicado en: | Nat Biotechnol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4430400/ https://ncbi.nlm.nih.gov/pubmed/25849900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3199 |
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