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The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.

Synovial fluid was collected from patients with recent knee injury and from patients with early or late stage osteoarthritis. Chondroitin sulfate-substituted aggrecan fragments present in these fluids, and in normal bovine synovial fluid, were purified by cesium chloride gradient centrifugation, enz...

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Bibliografski detalji
Glavni autori: Sandy, J D, Flannery, C R, Neame, P J, Lohmander, L S
Format: Artigo
Jezik:Inglês
Izdano: 1992
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC443022/
https://ncbi.nlm.nih.gov/pubmed/1569188
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