CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

We hypothesized that the combination of oncolytic virotherapy with immune checkpoint modulators would reduce tumor burden by direct cell lysis and stimulate antitumor immunity. In this study, we have generated attenuated Measles virus (MV) vectors encoding antibodies against CTLA-4 and PD-L1 (MV-aCT...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Mol Ther
Huvudupphovsmän: Engeland, Christine E, Grossardt, Christian, Veinalde, Rūta, Bossow, Sascha, Lutz, Diana, Kaufmann, Johanna K, Shevchenko, Ivan, Umansky, Viktor, Nettelbeck, Dirk M, Weichert, Wilko, Jäger, Dirk, von Kalle, Christof, Ungerechts, Guy
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2014
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429737/
https://ncbi.nlm.nih.gov/pubmed/25156126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.160
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk