CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

We hypothesized that the combination of oncolytic virotherapy with immune checkpoint modulators would reduce tumor burden by direct cell lysis and stimulate antitumor immunity. In this study, we have generated attenuated Measles virus (MV) vectors encoding antibodies against CTLA-4 and PD-L1 (MV-aCT...

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發表在:Mol Ther
Main Authors: Engeland, Christine E, Grossardt, Christian, Veinalde, Rūta, Bossow, Sascha, Lutz, Diana, Kaufmann, Johanna K, Shevchenko, Ivan, Umansky, Viktor, Nettelbeck, Dirk M, Weichert, Wilko, Jäger, Dirk, von Kalle, Christof, Ungerechts, Guy
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2014
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429737/
https://ncbi.nlm.nih.gov/pubmed/25156126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.160
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