CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

We hypothesized that the combination of oncolytic virotherapy with immune checkpoint modulators would reduce tumor burden by direct cell lysis and stimulate antitumor immunity. In this study, we have generated attenuated Measles virus (MV) vectors encoding antibodies against CTLA-4 and PD-L1 (MV-aCT...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Ther
Egile Nagusiak: Engeland, Christine E, Grossardt, Christian, Veinalde, Rūta, Bossow, Sascha, Lutz, Diana, Kaufmann, Johanna K, Shevchenko, Ivan, Umansky, Viktor, Nettelbeck, Dirk M, Weichert, Wilko, Jäger, Dirk, von Kalle, Christof, Ungerechts, Guy
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2014
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429737/
https://ncbi.nlm.nih.gov/pubmed/25156126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.160
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