CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

We hypothesized that the combination of oncolytic virotherapy with immune checkpoint modulators would reduce tumor burden by direct cell lysis and stimulate antitumor immunity. In this study, we have generated attenuated Measles virus (MV) vectors encoding antibodies against CTLA-4 and PD-L1 (MV-aCT...

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Publicado en:Mol Ther
Autores principales: Engeland, Christine E, Grossardt, Christian, Veinalde, Rūta, Bossow, Sascha, Lutz, Diana, Kaufmann, Johanna K, Shevchenko, Ivan, Umansky, Viktor, Nettelbeck, Dirk M, Weichert, Wilko, Jäger, Dirk, von Kalle, Christof, Ungerechts, Guy
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429737/
https://ncbi.nlm.nih.gov/pubmed/25156126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.160
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