Enhanced Control of Oncolytic Measles Virus Using MicroRNA Target Sites

Measles viruses derived from the live-attenuated Edmonton-B vaccine lineage are currently investigated as novel anti-cancer therapeutics. In this context, tumor specificity and oncolytic potency are key determinants of the therapeutic index. Here, we describe a systematic and comprehensive analysis...

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Veröffentlicht in:Mol Ther Oncolytics
Hauptverfasser: Leber, Mathias Felix, Baertsch, Marc-Andrea, Anker, Sophie Caroline, Henkel, Luisa, Singh, Hans Martin, Bossow, Sascha, Engeland, Christine E., Barkley, Russell, Hoyler, Birgit, Albert, Jessica, Springfeld, Christoph, Jäger, Dirk, von Kalle, Christof, Ungerechts, Guy
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026446/
https://ncbi.nlm.nih.gov/pubmed/29988512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2018.04.002
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