Effects of inorganic iron and myoglobin on in vitro proximal tubular lipid peroxidation and cytotoxicity.

Recent in vivo studies suggest that heme Fe causes proximal tubular lipid peroxidation and cytotoxicity, thereby contributing to the pathogenesis of myoglobinuric (Mgb) acute renal failure. Because hydroxyl radical (.OH) scavengers [dimethylthiourea (DMTU), benzoate, mannitol] can mitigate this inju...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Zager, R A, Foerder, C A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442948/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1311724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115682
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