Effects of inorganic iron and myoglobin on in vitro proximal tubular lipid peroxidation and cytotoxicity.

Recent in vivo studies suggest that heme Fe causes proximal tubular lipid peroxidation and cytotoxicity, thereby contributing to the pathogenesis of myoglobinuric (Mgb) acute renal failure. Because hydroxyl radical (.OH) scavengers [dimethylthiourea (DMTU), benzoate, mannitol] can mitigate this inju...

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Pubblicato in:	J Clin Invest
Autori principali:	Zager, R A, Foerder, C A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442948/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1311724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115682
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