High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells.
We studied the nature of insulin receptor binding in MCF-7 breast cancer cells. In both intact cells and solubilized receptor preparations, high-affinity insulin binding was seen. However, unlabeled insulin-like growth factor-I (IGF-I) was five-fold more potent in inhibiting 125I-insulin binding tha...
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| 發表在: | J Clin Invest |
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| Principais autores: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Clinical Investigation
1992
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442936/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1311720/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115670 |
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