Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.

We have investigated the metabolic actions of recombinant human IGF-1 in mice genetically deficient of insulin receptors (IR-/-). After intraperitoneal administration, IGF-1 caused a prompt and sustained decrease of plasma glucose levels in IR-/- mice. Plasma free fatty acid concentrations were unaf...

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Pubblicato in:	J Clin Invest
Autori principali:	Di Cola, G, Cool, M H, Accili, D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508095/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9153298/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119438
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