High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells.

We studied the nature of insulin receptor binding in MCF-7 breast cancer cells. In both intact cells and solubilized receptor preparations, high-affinity insulin binding was seen. However, unlabeled insulin-like growth factor-I (IGF-I) was five-fold more potent in inhibiting 125I-insulin binding tha...

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Εκδόθηκε σε:	J Clin Invest
Κύριοι συγγραφείς:	Milazzo, G, Yip, C C, Maddux, B A, Vigneri, R, Goldfine, I D
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Clinical Investigation 1992
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442936/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1311720/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115670
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