A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments

The DNA damage response kinase ATR may be a useful cancer therapeutic target. ATR inhibition synergizes with loss of ERCC1, ATM, XRCC1 and DNA damaging chemotherapy agents. Clinical trials have begun using ATR inhibitors in combination with cisplatin. Here we report the first synthetic lethality scr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mohni, Kareem N., Thompson, Petria S., Luzwick, Jessica W., Glick, Gloria G., Pendleton, Christopher S., Lehmann, Brian D., Pietenpol, Jennifer A., Cortez, David
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428765/
https://ncbi.nlm.nih.gov/pubmed/25965342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125482
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