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CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation

Polycomb and trithorax group proteins encode the epigenetic memory of cellular positional identity by establishing inheritable domains of repressive and active chromatin within the Hox clusters. Here, we demonstrate that the CCCTC-binding factor (CTCF) functions to insulate these adjacent yet antago...

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Publicat a:Science
Autors principals: Narendra, Varun, Rocha, Pedro P., An, Disi, Raviram, Ramya, Skok, Jane A., Mazzoni, Esteban O., Reinberg, Danny
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428148/
https://ncbi.nlm.nih.gov/pubmed/25722416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1262088
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